Revatio (Sildenafil): Legendary Viagra Substance Used in PAH Treatment

Overview, Uses of Revatio, Side Effects, Interactions, Precautions, Dosage and Overdose, Other Requirements and Reviews

Product Overview
Revatio (Sildenafil): Legendary Viagra Substance Used in PAH Treatment
Other Names:
Sildenafil Citrate
Active ingredient:
Sildenafil Citrate
Dosages (mg):
Drug Class:
Phosphodiesterase type 5 (PDE5)
Pulmonary Arterial Hypertension (PAH) treatment
20 mg
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Revatio Overview

Revatio is a prescription medication used to treat adults with pulmonary arterial hypertension (PAH). Revatio belongs to a group of drugs called PDE inhibitors. Revatio treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily.

Revatio Overview

Revatio comes in tablet and oral suspension (liquid) form and is taken taken 3 times a day, 4-6 hours apart. This medication also comes in an injectable form to be given directly into a vein (IV) by a healthcare professional. Common side effects include nosebleeds, headache, indigestion, and flushing.

Uses of Revatio

Revatio is a prescription medication used to treat adults with pulmonary arterial hypertension (PAH). This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Side Effects of Revatio

The most common side effects of Revatio are:

  • nosebleeds
  • indigestion
  • headache
  • flushing of the face
  • difficulty falling or staying asleep
  • runny nose

Revatio may cause other side effects besides those listed.

If you want more information or develop any side effects or symptoms you are concerned about, talk to your doctor or pharmacist.

Revatio Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Especially tell your doctor if you take any of the following:

  • medicines called alpha blockers. These include Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl) or Uroxatral (alfuzosin HCl). Alpha blockers are sometimes prescribed for prostate problems or high blood pressure. If sildenafil is taken with certain alpha blockers, your blood pressure could suddenly drop and you could get dizzy or faint.
  • other medicines to treat high blood pressure (hypertension)
  • medications that block a protein in the body (CYPA4) such as some macrolide antibiotics (clarithromycin, telithromycin), some HIV protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir), some HCV protease inhibitors (boceprevir, telaprevir), some azole antifungals (ketoconazole, itraconazole, posaconazole, voriconazole), conivaptan (Vaprisol), delavirdine (Rescriptor), and nefazodone (Serzone)
  • medicines or treatments for Erectile dysfunction.

Do not take Revatio if you take any medicines called “nitrates.” Nitrates are commonly used to treat angina. Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm.

  • Medicines called nitrates include nitroglycerin that is found in tablets, sprays, ointments, pastes, or patches. Nitrates can also be found in other medicines such as isosorbide dinitrate or isosorbide mononitrate. Some recreational drugs called “poppers” also contain nitrates, such as amyl nitrite and butyl nitrite.
  • Ask your healthcare provider or pharmacist if you are not sure if any of your medicines are nitrates.

This is not a complete list of Revatio drug interactions. Ask your doctor or pharmacist for more information.

Revatio Precautions

  • Revatio is not for newborns, children, or women.
  • Do not let anyone else take your Revatio.
  • Revatio can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines.
  • Seek immediate medical attention if sudden loss of vision occurs, which could be a sign of non-arteritic ischemic optic neuropathy (NAION).
  • Seek immediate medical attention if sudden decrease or loss of hearing occurs.

Do not take Revatio if you:

  • take any medicines called “nitrates”. See "Drug Interactions" section.
  • use recreational drugs called “poppers” like amyl nitrite and butyl nitrite
  • are allergic to Revatio or any of its ingredients. Symptoms of an allergic reaction may include:
    • rash
    • hives
    • swelling of the lips, tongue, or throat
    • difficulty breathing or swallowing
  • Call your healthcare provider or get help right away if you have any of the symptoms of an allergic reaction listed above.
  • Only your doctor can decide if Revatio is right for you. Revatio can cause mild, temporary lowering of your blood pressure.

Less common side effects that may occur are temporary changes in color vision (such as trouble telling the difference between blue and green objects or having a blue color tinge to them), eyes being more sensitive to light, or blurred vision.

In rare instances, men taking PDE5 inhibitors reported a sudden decrease or loss of vision in one or both eyes. It is not possible to determine whether these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, or to a combination of these. If you experience sudden decrease or loss of vision, stop taking PDE5 inhibitors, including Revatio, and call a doctor right away.

In rare instances, men have reported an erection that lasts many hours. You should call a doctor immediately if you ever have an erection that lasts more than 4 hours. If not treated right away, permanent damage to your penis could occur.

Sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness, has been rarely reported in people taking PDE5 inhibitors, including Revatio. It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors. If you experience these symptoms, stop taking Revatio and contact a doctor right away.

Revatio Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Revatio, there are no specific foods that you must exclude from your diet when receiving this medication.

Revatio Usage

Revatio comes in tablet and oral suspension (liquid) form and is taken 3 times a day, 4-6 hours apart.

To prepare the oral solution:

  1. Tap the bottle to release the powder.
  2. Remove the cap.
  3. Accurately measure out 60 mL of water and pour the water into the bottle.
  4. Replace the cap and shake the bottle vigorously for a minimum of 30 seconds.
  5. Remove the cap.
  6. Accurately measure out another 30 mL of water and add this to the bottle. You should always add a total of 90 mL of water irrespective of the dose prescribed.
  7. Replace the cap and shake the bottle vigorously for a minimum of 30 seconds.
  8. Remove the cap.
  9. Press the bottle adaptor into the neck of the bottle. The adaptor is provided so that you can fill the oral syringe with medicine from the bottle. Replace the cap on the bottle.
  10. Write the expiration date of the constituted oral suspension on the bottle label (the expiration date of the constituted oral suspension is 30 days from the date of constitution).

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Revatio Dosage

For the treatment of pulmonary arterial hypertension (PAH):

Revatio tablets and oral solution: The recommended dose of Revatio (sildenafil) is 20 mg three times a day. Take Revatio doses 4–6 hours apart. Doses higher than 20 mg three times a day is not recommended.

Injectable: The recommended dose is 10 mg (12.5 mL) given as an injection into the vein (IV) three times a day.

Revatio Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

Keep Revatio out of the reach of children. Keep Revatio in its original container. Store at room temperature away from excessive heat or moisture.

My Canadian Pharmacy Customer Reviews

I didn't think this drug was effective at all; in fact, my doctor took me off of it at my request. After a day without I soon relized it had been extremely effective for my hypertention. Without it I couldn't even make it across my living room. I'm not perfect when I'm on it but I can at least resume some household actvities.

Paige, 45-54 Female on Treatment for less than 1 month (Patient)

My lung fuction was 10 once I started on this medacine my lungs have a 95% function it saved my life

bizzybea2, 75 or over Female on Treatment for 2 to less than 5 years (Patient)

I am 47 always been healthy,no cause or reason for my condition which came up suddenly this year, They call it idiopathic (no reason) My 02 levels were low with physical activity and my right heart pressures were moderate(62)but only found this after a right heart cath, no other test showed any problems, including 3 echo cardio grams. Since taking the drug after one month I have had improved O2 saturation levels and can now walk around slowly without O2 tank attached to my side. My 02 levels would drop in the low 80s all the time, now they stay in the upper 80s and low 90s while walking and are still improving. cost about 1800.00 a month I pay $45 with insurance at 20mg 3 times a day. re-evaluation after 3 months to see how things go but I deffinately feel better and have absolutely no side effects other than a slight burn in my throat now and then like a acid reflex but will go away with eating food when taking the meds. No blurred vision from the meds but I was having slight blurred vision at close ranges in low light, like reading a menu at a resturant,this I think was caused from the low 02 levels, fixed with reading glasses, maybe its just from getting older but I have no color issues or any other problems with taking the meds.

kngkop, 45-54 Male on Treatment for 1 to 6 months (Patient)

After being on the med for two weeks I was able to go up a flight of stairs that I previously had to struggle to climb.

travel9140, 65-74 Female on Treatment for 1 to 6 months (Patient)