Viagra Super Active is among the top-selling generic sildenafil products in Canada and worldwide. This medication is available in four distinct dosage levels, designed for patients with erectile dysfunction varying from mild to severe.
Ingredients and general information
With the advance of generic Viagra on the market, the number of competitors has increased dramatically. This increased competition between manufacturers is almost always an additional boost to the decline in generic sildenafil prices. Viagra Super Active is thus offered at a lower price than the reference drug. A medical benefit resulting from the vast selection available in the market includes a higher availability of formulations that can better cater to each patient's individual needs.
Viagra generics are available in the form of orodispersible tablets, which despite the same effect, are easier to use. In some cases, individual tolerability to sildenafil has been recorded because of the difference in excipients compared to the original drug. This is in fact a great advantage of several manufacturers of the same pharmaceutical product: some properties vary from brand to brand and always based on the same active ingredient, it is possible to adapt the treatment to the singularities of each patient.
Does Viagra Super Active work?
As said above, sildenafil, which aims to help patients suffering from erectile dysfunction, was discovered by chance when scientists performed tests on patients with lung diseases and noticed that they had erection as a side effect. That was exactly what millions of men needed to deal with the problem of sexual dysfunction. This was fundamental and very important for the story, considering that impotence is a stigma, whose patients who suffer from this problem have many psychological problems and low self-esteem.
Starting from the first few intakes and on (with the tendency of increased efficacy with every follow-up dose), 4 out of 5 men who experience Viagra Super Active develop a sufficient erection for sex. Viagra Super Active works because it is a drug that inhibits phosphodiesterase-5, an enzyme that impairs the erection process. It promotes the relaxation and irrigation of the penis through sexual stimulation. During clinical trials of Viagra Super Active for the treatment of ED, considerable improvements in this condition was observed even in men with full ED, where the achievement of erection is completely impossible without medicating.
Expiration of the original patent made room for the appearance of generic sildenafil - the active ingredient of Viagra Super Active. Viagra Super Active continues to be one of those consistently repurchased for the treatment of ED, but the risks associated with shopping from indiscrete online pharmacies involves significant dangers to your health. The supply of drugs for erectile dysfunction online is great, and it should be noted that generic or original sildenafil is only sold online even though a medical prescription is passed remotely by a doctor. Buying this type of medication on sites that sell it freely without any prescription can lead to health risks because they are not authentic medicines.
There are many counterfeits in the market, so the drug purchased through these uncertified sites may not have the desired effect and have serious health consequences. However, through sites like My Canadian Pharmacy Rx, the patient can get access to high-quality drugs accompanied by the proper advice online to be able to reap maximal health benefits from the use of Viagra Super Active.
Available Dose - 100mg
Viagra Super Active comes in one dose: sildenafil 100mg. This diversifies your choice for a perfectly tailored dose that yields optimal health outcomes and minimal side effects. Always consult your doctor before choosing in favor of any of the above. Self-administration of drugs is a dangerous practice. But do you know the right dose of the drug in your case? If you have doubts then the time has come to clarify them.
According to the guidelines in its package leaflet, the use of Viagra Super Active is per os, with the most common dose applied and guided by doctors is 100mg and the use of only one tablet per day. This dose is indicated at the start of treatment, so it is the first time you take the medicine and do not exceed this dose and follow exactly what your doctor advises.
Effects in the body
Sildenafil is a type 5 phosphodiesterase inhibitor, specific to cGMP (cyclic monophosphate guanosine); type 5 phosphodiesterase is mainly located in the smooth muscle of the vessels of the cavernosa body of the penis and is the enzyme responsible for the cGMP degradation (cyclic monophosphate guanosine); Therefore, inhibition of this enzyme by sildenafil leads to a higher concentration of cGMP (cyclosporin monophosphate guanosine), which results in more intense vasodilation, hence in a more vigorous erection due to the greater supply of blood to the penis. Thus, we can say that sildenafil does not produce a direct relaxing effect on the cavernous body, but it effectively increases the effect of nitric oxide (NO) on the smooth muscle of the cavernous body itself: when the NO / cGMP path is activated, such as during sexual stimulation, sildenafil inhibition of type 5 phosphodiesterase leads to a significant increase in cGMP levels in the cavernous body.
Safety studies
What makes Viagra Super Active special is its selectivity for type 5 phosphodiesterase (PDE5), the enzyme involved in the penile erection process. From in vitro studies, it has been noted that the affinity of sildenafil to other phosphodiesterases is generally low, and varies according to the type of phosphodiesterase considered. For example, the selectivity for PDE6, an anzyme involved in retinal phosphatography, is 10 times lower than that shown for PDE5, while sildenafil selectivity for PDE3 is about 4,000 times lower than the selectivity shown towards PDE5.
Other clinical trials have been conducted with the aim of assessing the time interval from the time of taking the drug at the time when sildenafil begins to take effect; since the patient does not always know if he or she will need the help of the drug, knowing exactly the length of this interval would be very helpful. Following the administration of sildenafil to patients with an empty stomach, the appearance of the desired effect was observed in a range ranging from 12 to 37 minutes, with an average of 25 minutes, while the duration of the drug's positive effect on erection can continue up to 4-5 hours after taking it, even when you have a sexual stimulation. Other studies have been conducted to observe the effects of sildenafil on the cardiovascular system. In general, it has been noted that sildenafil does not cause any alteration of heart output and does not in any way compromise blood circulation through coronary arteries. In fact, the administration of sildenafil at doses up to 100 mg in healthy volunteers did not produce any clinically significant effect on the electrocardiogram.
Administration of the drug was also carried out in subjects suffering from severe coronary artery disease, to study the possible adverse effects; in these patients, after sildenafil administration, only a slight decrease in systolic and diastolic blood pressure was noted, as well as a reduction in systolic pulmonary blood pressure of about 9%. After about one hour after administering a dose of 100 mg of sildenafil, some subjects were observed to have a somewhat undesirable effect: a slight variation in color perception, namely blue and green, an effect attributed to all 'inhibition by PDE 6 enzyme sildenafil, which as we have seen is part of the cascade phototransduction process in the retina. This effect disappeared spontaneously within two hours after administration of the drug.
In another study, the positive effect of sildenafil on the treatment of erectile dysfunction has been studied in patients with various pathologies that compromise the erection and sex life of the patient. In this study, about 3,000 patients aged between 19 and 87 who had pathologies such as hypertension, cardiovascular disease and ischemic heart disease, diabetes mellitus, spinal cord injury, hyperlipidemia, depression and transurethral prostate resection were considered. The above mentioned patients, after the administration of sildenafil, have shown a marked improvement in the achievement of erection; more precisely, 62% of patients responded positively at the dose of 25 mg of sildenafil, 74% of respondents responded positively to 50 mg and 82% of patients responded positively to the dose of 100 mg of sildenafil.