My Canadian Pharmacy Doctor About Cialis Side Effects, Warnings, Contraindications And Interactions

Cialis and its generics are a long-time bestseller and an absolute hit with customers of My Canadian Pharmacy. The pill is a long-acting marathoner that will have your back during 36 hours, regardless of meals and drinks ingested. However, there is still a room for improvement – our doctors would like to reiterate certain safety points of Cialis use.

For a touch-up on your knowledge about Cialis effects, benefits, uses and drugs containing generic tadalafil, feel free to visit these pages: mycanadianpharmacypro.com/generic-cialis

Contraindications and warnings for use

Contraindications and warnings for use

Before starting a pharmacological treatment for erectile dysfunction, it is advisable to conduct a series of examinations and a specialist visit to get an accurate diagnosis of the problem and to know the nature of the causes of the disorder. Since tadalafil is a drug that has vasodilatatory properties, when administered it can cause a slight decrease in blood pressure; therefore, before starting the treatment of erectile dysfunction with tadalafil, doctors should undertake a series of examinations to evaluate the cardiovascular conditions of their patients, also because there is a potential for cardiac events related to sexual activity.

In fact, after the marketing of tadalafil, some cardiovascular events such as ventricular arrhythmia, chest pain, angina pectoris, ischemic attacks, stroke, palpitations and tachycardia have emerged from some patients’ experiences and some clinical trials; it should be noted, however, that almost all patients who suffered from these events had cardiovascular risk factors before they started taking tadalafil.

Another category of patients to whom attention should be taken when administering tadalafil are those with impaired renal and hepatic function; particularly patients with severely impaired renal or hepatic function should not take tadalafil, also because there is insufficient clinical data on the safety of tadalafil when taken by this particular group of patients.

The administration of tadalafil in patients with anatomic deformations of the penis – such as anorexia or cavernous fibrosis – or who suffer from pathologies that may cause priapism following drug administration – such as sickle cell anemia or multiple myeloma – should be exercised with extreme caution. If, unfortunately, after an inhalation of tadalafil occurs an erection lasting more than 4 hours, the patient is advised to seek immediate health care: it would be a form of non-permanent priapism which, in the absence of timely treatment, could causing damage to the penis tissue and in the worst cases the appearance of permanent impotence.

Tadalafil interaction with other drugs

Tadalafil is metabolised by the cytochrome P450 enzymatic group, in particular by the CYP3A4 isoenzyme, so there is a possibility that simultaneous administration to strong CYP3A4 inhibition inhibitors may alter the plasma concentrations of tadalafil. Indeed, in some clinical trials conducted on patients who had been coadministered with tadalafil and ketoconazole, which is a strong inhibitor of CYP3A4, at therapeutic doses, the maximum plasma concentration of tadalafil was increased by about 15% compared to normal, while its plasma bioavailability was doubled compared to normal, ie when tadalafil is administered alone.

During these clinical trials, tadalafil was also given with ritonavir, a protease inhibitor, which is also a major inhibitor of a large group of isoenzymes of the cytochrome P450 enzymatic system, consequently also of CYP3A4; after this simultaneous administration of the two drugs, the plasma bioavailability of tadalafil was approximately 2-fold higher than the normal one, while its maximum plasma concentration remained unchanged from normal. No evidence of simultaneous administration of tadalafil with other CYP3A4 inzulins, such as clarithromycin, itraconazole, other protease inhibitors, or grapefruit juice, has not been performed in the above-mentioned clinical trials; however, clinical experience and the membership classes of these substances suggest that such administration should be avoided; if this combination of tadalafil was inevitable, it is recommended to separate the intake times and if necessary adjust the dose of tadalafil.

Rifampicin, on the other hand, is a drug that increases the rate of metabolism of the CYP3A4 insecticide; Consequently, if administered simultaneously with tadalafil, it reduces plasma bioavailability by about 80-90% by effectively reducing its effectiveness; therefore, it is also recommended in this case to avoid the simultaneous intake of the two drugs.

Tadalafil is a drug with light hypotensive properties, therefore it can alter the efficacy and pharmacodynamics of antihypertensive drugs administered at the same time. For this reason, several clinical trials have been performed simultaneously with tadalafil with some of the most widely used antihypertensive drugs. These studies have shown that tadalafil increases the antihypertensive effect of drugs belonging to the category of organic nitrates taken at the same time; therefore the administration of tadalafil together with organic nitrates is contraindicated; in cases where such administration is inevitable, it is recommended to change the intake times and, if necessary, to adjust the dose of tadalafil; It is also recommended that this intake be continuously monitored and monitored by your healthcare professional so as to avoid unpleasant side effects that may arise from enhancing the antihypertensive effect of organic nitrates.

In these clinical trials, antihypertensive drugs belonging to other categories, such as amlodipine (belonging to the class of calcium antagonists), enalapril (angiotensin converting enzyme inhibitor class or ACE-inhibitors), metoprolol (class of blockers of betta-adrenergic receptors) and hydrochlorothiazide (class of diuretic drugs). These drugs were administered concurrently with 10 mg tadalafil without any significant additional reduction in blood pressure. In the other group of patients, however, where anti-hypertensive drugs were administered with 20 mg of tadalafil at the same time, blood pressure lowering was noted, but this decrease was not large and could not be clinically significant.

However, although clinical trials have not shown any lowering of blood pressure in the case of simultaneous intake of tadalafil and the antihypertensive agents mentioned above, caution is however advised and the physician should be consulted in advance.

My Canadian Pharmacy breaks down side effects of Cialis

Cialis is only available on prescription. It is a drug widely adopted by male people suffering from erectile dysfunction. Most men take this treatment against impotence without encountering the slightest side effect. However, as any prescription drug Cialis can cause some of the side effects. These unwanted effects of Cialis are usually mild and pose no danger. You have to know that every person reacts differently to a drug. Some will be subject to several adverse effects while others will not experience any side effects.

The side effects of Cialis on the body have been extensively studied in numerous clinical trials before its introduction on the market. More than 15,000 people were treated with Cialis during these studies. Since its introduction on the market, Cialis has helped millions of couples regain a fulfilling sexual life.

Canadian Pharmacy breaks down side effects of Cialis

Common side effects: Some side effects occur commonly at the beginning of treatment. They are usually benign and disappear quickly. In case of persistent or more troublesome effects, it is advisable to consult a doctor.

Uncommon side effects: Meet this type of effects (see table below), should not alert you. These adverse effects are less frequent although encountered in some cases. Most of these symptoms disappear after a few hours. If this is not the case, consult a doctor.

Rare side effects: These side effects of Cialis are rare and more serious. They affect about 1 in 10,000 patients. If any of these effects happen, you should contact a doctor as soon as possible. These effects may result from the use of several combination therapies that result in a drug interaction. It may also be an allergic reaction to tadalafil or another health problem. In all cases, a medical diagnosis is essential.

Precision on the duration of side effects of Cialis: Tadalafil, active ingredient of Cialis, remains active in the body longer than other molecules treating male impotence. Its possible side effects may therefore be felt over a longer period of time and cause real discomfort. If this happens, it may be helpful to reduce the dosage of Cialis in accordance with the advice of a doctor. The most common side effects affecting up to 10% of all Cialis patients are headache, back, muscle, leg and shoulders, as well as facial flushing, stuffy nose, indigestion and reflux.

Very rare side effects include dizziness, stomach and eye pain, visual disturbance, sweating, hypotension, nasal or penile bleeding, ringing in the ears, difficulty breathing, sperm or urine, palpitations and hypertension. These side effects occur in up to 1% of all patients.

Taking Cialis is also associated with the likelihood of syncope, memory disorders, swelling of the eyelids, redness of the eyes, sudden hearing loss and urticaria (itchy skin, view more info). These side effects, however, are extremely rare. They were only reported in 0.01% of patients.

Other very rare side effects are: migraines, facial and pharyngeal swelling, rash, blood flow to the eyes, irregular heartbeat, angina pectoris, myocardial infarction, temporary or permanent loss of vision, diarrhea, stroke or priapism (long-term painful erection).

The most common side effects affecting up to 10% of all Cialis patients are headache, back, muscle, leg and shoulders, as well as facial flushing, stuffy nose, indigestion and reflux. Very rare side effects include dizziness, stomach and eye pain, visual disturbance, sweating, hypotension, nasal or penile bleeding, ringing in the ears, difficulty breathing, sperm or urine, palpitations and hypertension. These side effects occur in up to 1% of all patients.

Taking Cialis is also associated with the likelihood of syncope, memory disorders, swelling of the eyelids, redness of the eyes, sudden hearing loss and urticaria (itchy skin). These side effects, however, are extremely rare. They were only reported in 0.01% of patients.

Other very rare side effects are: migraines, facial and pharyngeal swelling, rash, blood flow to the eyes, irregular heartbeat, angina pectoris, myocardial infarction, temporary or permanent loss of vision, diarrhea, stroke or priapism (long-term painful erection).

What to do if side effects occur?

Contact your doctor if any of these side effects occur. Immediate medical care should be sought especially in the event of ailments such as allergic reactions, sudden loss of vision or chest pain (under no circumstances should nitrate be used in this case).

The doctor’s help should also be sought in the event of a persistent, painful erection that persists for more than 4 hours. The condition is known as priapism.

Cialis and priapism

Priapism is a phenomenon of experiencing uncontrolled, long-lasting and painful erections. It is caused by the trapped blood inside the spongy tissue of the penis. This is one of the side effects that may occur as a result of taking any medicine for potency. Priapism is not usually associated with sexual arousal and persists even after ejaculation.

More about priapism: https://www.mycanadianpharmacypro.com/priapism

If the patient experiences persistent erection, he or she should go to a medical facility as soon as possible because priapism can have very dangerous health consequences. Neglecting the problem often leads to permanent damage to the penis. There are several procedures in case of this condition. These involve the discharge of blood from the penis by means of a syringe or by injection directly into the penis of the vasodilators.

My Canadian Pharmacy Infographics: Minimize The Risk Of Cialis Side Effects

To reduce the risk of side effects, you may wish to follow the instructions in the graphics below.

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