A Comprehensive Guide To Choosing The Right Cialis Dose: 5, 10, 20, 40mg

Cialis dosagesWith the development of inhibitors of phosphodiesterase type 5 in the treatment of erectile dysfunction (ED), the revolution occurred. Cialis is the newest and most versatile PDE5 inhibitor for a medical treatment of impotency. In pharmacies, it is sold without a prescription. Pathophysiology of erectile dysfunction has many causes, including psychological, hormonal, neurogenic, vascular, or those caused by drug use or cavernous impairment from any of the above-mentioned factors. The most common type of ED is a mixture of psychogenic and organic causes.

In May 2002, during the 97th annual meeting of the American Urological Association in Orlando, USA, the first reports on the efficacy and duration of the active substance of Cialis, tadalafil, for ED were presented. Tadalafil was approved for use in Europe in 2002, and in 2003 it was approved by the FDA for use in the United States. The most unique characteristic of this drug is its long elimination half-life (and therefore, duration of action) – 17,5 hours for young men and 21,7 hours for the elderly individuals in comparison with the half-life of sildenafil (Viagra) and vardenafil (Levitra) that is about 4 hours. Clinical trials have proven safety and efficacy of Cialis for all severity levels and ED etiology, including impotency that is difficult to cure.

Therapy Course with Cialis

The drug is to be taken not oftener than once a day. Cialis is administered only after consultation by a specialist, andrologist or sexologist. The maximum recommended dose of Cialis is 20 mg. A tablet is taken before sexual intercourse.

A patient should observe the following recommendations:

  • If a person has renal disease, the recommended dose of Cialis is 10 mg. This dose can be increased to 20 mg. For patients with severe renal failure, 10 mg is maximally recommended dose.
  • If a man has a hepatic disorder, the recommended dose of Cialis is 10 mg. Patients with severe hepatic impairment should be guided by their physician’s advice.
  • For elderly people or people with diabetes, no special dosage is required.
  • With symptoms associated with benign prostatic hyperplasia, the recommended dose of the drug is 5 mg.
  • Tablets are taken once a day. A tablet should be washed down with a full glass of water.
  • Cialis requires in average 2 hours for reaching its maximum concentration, compared with approximately 50 minutes needed for sildenafil and vardenafil.
  • Find out more My Canadian Pharmacy recommendations in this guide no Cialis: mycanadianpharmacypro.com/generic-cialis.

Nuances of Cialis Administration

Nuances of Cialis AdministrationDifferences in gastrointestinal absorption of fatty food explain different maximum plasma concentration of between three PDE5 inhibitors (Cialis, Viagra and Levitra). The intake of Viagra and Levitra with fatty food is characterized by their low efficiency, whereas the absorption of Cialis affects neither by fatty food, nor by the consumption of alcohol. This unique pharmacokinetic feature of Cialis is the result of a slower absorption and a longer elimination half-life.

Cialis Composition

One tablet of Cialis contains 5, 10, 20, or 40 mg of tadalafil + auxiliary components: croscarmellose sodium, hydroxypropyl cellulose, hydroxypropyl methylcellulose, ferrum oxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, talc, titanium dioxide and triacetin.  This medicine does not contain sucrose, gluten, tartrazine, or any other colorants.

Mode of Action

The enzyme phosphodiesterase type 5 prevents from erection by cleavage of the cyclic guanosine monophosphate (cGMP). The substance of cGMP is needed to expand the arteries of penis so that they are better filled with blood and supplied with oxygen. Inhibitors of phosphodiesterase type 5, such as tadalafil, do not give PDE5 to cleave cGMP. This allows penis to be filled with blood and stay erected long enough for sexual intercourse. Advantage of Cialis pill lies in the fact that tadalafil remains active in body much longer than other drugs. Viagra and Levitra function for about four to five hours (and sometimes up to 12 hours), whereas Cialis action ranges from 24 to 36 hours.

Forms and Dosages of Cialis: 2.5, 5, 10, 20mg

There are following forms of the preparation Cialis:

  • Cialis 2.5 mg – yellow-orange, almond-shaped, film-coated tablets. They contain 2.5 mg of tadalafil;
  • Cialis 5 mg (to be applied once a day) – yellow, almond-shaped tablet with film coating. It contains 5 mg of tadalafil.
  • Cialis 10 mg – each yellow, almond-shaped tablet with film coating contains 10 mg of tadalafil.
  • Cialis 20 mg – orange, almond-shaped tablets with film coating contain 20 mg of tadalafil.

Cialis is not available in the form of jelly, but there is a generic preparation Apcalis, which is an analogue of the original Cialis. It is available in the form of jelly and is intended for the treatment of erectile dysfunction. There is also generic Cialis 40 mg. Cialis dapoxetine and Cialis forte that are designed for improvement of male potency. The first drug contains a combination of tadalafil 20 mg and dapoxetine 60 mg. The second medicine contains various herbal substances, as well as zinc oxide, L-arginine, indole-3-carbinol, quercetin and vitamins (B6, B9, B12).

Posology and Administration: Dosage Guide

  1. Forms and Dosages of CialisThe recommended dose for a single dose of Cialis is 20 mg. This dosage is not changed for patients of different ages and can be used both in 18 years and after 65.
  2. Depending on the severity of erectile dysfunction, concomitant diseases and tolerability of the drug, the dose can be reduced to 10, 5 or 2.5 mg.
  3. For men with a violation of liver function from mild to moderate degree, the maximum dose of Cialis should not exceed 10 mg.
  4. Dosage recommended for patients with renal dysfunction is 5 mg or 10 mg once per 2 days. As per recommendation of a doctor for these diseases, the dose of tadalafil can be reduced to 2.5 mg.
  5. If a patient is treated with strong inhibitors of cytochrome P3A4, such as ketoconazole, erythromycin, itraconazole, ritonavir and others, the maximum dosage of tadalafil should be 10 mg once per 3 days.

Tadalafil in the composition of Cialis has a long range of action. A man with ED is able to perform sexual intercourse within 36 hours. This unique feature of tadalafil allows Cialis to be considered as the best regulator of potency among its counterparts. For comparison: Viagra’s action lasts up to 6 hours, Levitra’s one – up to 10 hours.

Time after taking Cialis before the onset of erection is 20-30 minutes. Cialis can be taken with food, alcohol or without them. However, drinking alcohol can affect men’s ability to achieve erection, so excessive consumption of alcohol should be refused.

Therapy course with Cialis for erectile dysfunction should be performed with the dose of 10 mg or 20 mg of tadalafil. A pill is to be taken at least 30-60 minutes before the expected sexual activity. The amount of time it takes for a drug to work out varies from person to person. For some men, Cialis takes action in 16 minutes after taking the pill, but for the first time it is recommended to take it at least an hour before sex. Cialis is effective for 36 hours, that is, after its reception, you can achieve an erection (with sexual stimulation) in any time for 36 hours.

Preparations related to inhibitors of PDE5 are designed for regular episodic administration. A certain course with Cialis does not exist. Many things, such as body weight, illnesses and taking medications can affect the dose of medicine that is needed by a person. If your doctor recommends a dose different from that indicated in the article, follow the advice of the doctor. After three months of taking Cialis, erectile function improves in the form of spontaneous erections.

Cialis is the only drug for impotency the low dose of which is suitable for daily use. The initial dose is 2.5 mg; if this dosage does not work, the daily dose can be increased to 5 mg.


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