The Long-Term Effects of Cialis 5 Mg Therapy Course

Erectile dysfunction is a condition that impacts the daily lives of millions of men all across the globe. Fortunately, we are lucky enough to live in times when effective and safe drugs are available to treat the condition. Cialis is a medication used by many to treat erectile dysfunction thanks to its advantages when compared to other drugs for the same purpose. Understanding how Cialis for daily use works and its impact on the body long term is important, as it gives you an idea of how your body is influenced by the drug.

Erectile dysfunction and its causes

Erectile dysfunction is a health condition that is characterized by the inability to achieve and/or maintain penile erections for the duration that is enough to have a satisfactory sexual experience. This health issue becomes more and more common among men of different ages because of how numerous people lead inactive lifestyles and have diets that do not contribute to their vascular health. Erectile dysfunction is most often caused by various cardiovascular problems, such as heart disease, atherosclerosis, etc. These conditions disrupt the proper blood circulation in the body, which causes men to experience problems attaining or maintaining erections. It’s only natural that men diagnosed with ED experience a lot of psychological discomfort due to this condition, which is why adequate treatment plays such an important role.

PDE5 inhibitors: which types are available?

Erectile dysfunction and its causes

Nowadays, the most widely used drugs for the treatment of ED belong to the group of selective phosphodiesterase type 5 (PDE5) inhibitors. The drugs are prescribed and used because of their high levels of effectiveness as well as safety. At the moment, there are three PDE5 inhibitors approved by FDA and they include Viagra (Sildenafil), Levitra (Vardenafil), Stendra (Avanafil), and Cialis (Tadalafil). All of the mentioned drugs have been thoroughly tested and proven to be effective in the management of ED symptoms. It needs to be mentioned that PDE5 inhibitors do not cure ED but they influence the erectile function in a way that enables men to get erections and have normal sex during a set period of time. While belonging to the same group, these ED medications differ in their potential side effects, duration of influence, and more. In addition to that, the individual reactions of patients when taking any of these drugs can vary.

How To Treat Erectile Dysfunction? Read Interview With Dr. Jonathan Blazer: mycanadianpharmacypro.com/erectile-dysfunction

Cialis – the most long-lasting PDE5 inhibitor

Cialis was approved by FDA in 2008 after Viagra and Levitra already entered the market and were used by patients. When we compare this drug with other three available PDE5 inhibitors, there are some differences exhibited by Cialis. Firstly, the influence of the active ingredient Tadalafil doesn’t get disturbed by the consumption of fatty meals and moderate amounts of alcoholic beverages. Secondly, what makes Tadalafil stand out from its competitors is the prolonged influence because of its long elimination half-life that takes about 18 hours. A single Cialis pill gives men an opportunity to get erections over the period of up to 36 hours. The benefit of such duration of influence is that it allows men and their partners to be more spontaneous when it comes to engaging in sexual activities.

While this advantage of Tadalafil is appreciated by patients, the prolonged influence of the drug is also associated with more long-lasting adverse reactions, such as myalgia and headaches.

Cialis as a PDE5 inhibitor: the mechanism of action

Cialis as a PDE5 inhibitor the mechanism of action

The process of getting an erection is complex and it involves the work of several systems in the body. When a man experiences arousal, nitric oxide gets released from cells and nerve terminals in the corpus cavernosum, which is the spongy tissue located in the penis. During this process, nitric oxide (NO) triggers guanylate cyclase that in its turn converts guanosine triphosphate to cyclic guanosine monophosphate (referred to as cGMP). Once there is enough cGMP accumulated in the body, it causes the relaxation of the smooth muscle in a man’s corpus cavernosum. As a result of this process, the supply of blood to the penis improves, thus allowing a man to get a firm erection.

PDE5 is a type of an enzyme which is mostly located in the smooth muscle of the penis and its purpose it to selectively degrade cGMP to 5’-GMP. When it comes to the mechanism of action of PDE5 inhibitors, such as Cialis, they are similar in their structure to cGMP. The way they allow a man to prolong an erection is by binding to the natural PDE5 enzyme in the body and inhibiting the hydrolysis of cGMP, which leads to the stronger effects of NO.

It should be stated that regardless of the active ingredient, PDE5 inhibitors do not cause the relaxation of the smooth muscle without sexual stimulation. In such a way, arousal is an essential part of the process that allows a drug to work and if a man doesn’t experience any sexual stimulation he won’t get a spontaneous erection after taking this drug.

Long-term use of Cialis: is it safe?

According to the study conducted over the course of 24 months and involving over a thousand men suffering from erectile dysfunction, Cialis is a safe and well-tolerated medication. The average age of the patients taking part in the research was 57 years old. The starting dose approved for the study was 10 mg of Cialis, but it could either be increased to 20 mg in patients that didn’t get the needed results or reduced to 5 mg in those experiencing adverse effects.

The most common adverse reactions experienced by patients during the treatment included:

  • Headache
  • Dyspepsia
  • Nasopharyngitis
  • Back pain

The discontinuation rate because of the serious adverse reactions during the 24 months of the study was 6.3% while more severe side effects were noticed in 8.6% of all patients consuming Cialis. In such a way, Cialis can be safely used long-term in patients of different ages but it’s important to adjust the dosage according to the individual reactions. In case the Cialis side effects persist even when taking the minimal dosage, the medication may not be right for a patient, and the treatment should be continued using a different medication.

How is Cialis consumed?

Just it was mentioned previously, Cialis is a drug that should be taken when needed i.e. before you plan to have sex. Thanks to the fact that it provides the results for up to 36 hours, you don’t need to rush and you can decide when you want to have sex and be spontaneous. The minimum waiting time for the drug to start working is 15-30 minutes on average. It is best to pay attention to how your body responds to the medication to determine how much time it takes for the pill to work in your case.

How is Cialis consumed?

You don’t need to take Cialis on an empty stomach, as it’s compatible with fatty meals and moderate amounts of alcohol. The pill should be consumed with a sufficient amount of water without crushing or chewing.

When we talk about the dosing, the minimum Cialis dosage of 2.5 mg is often initially prescribed to the patients over the age of 65 to see how the body responds to the drug. 5 mg and 10 mg are the standard initial dosages in the majority of cases. Patients that don’t experience the improvement taking 10 mg of Cialis and don’t get any side effects to the drug can increase the dosage to 20 mg if recommended by a medical specialist.

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